Applications

FA

Synonyms:

Compound C, AMPK Inhibitor, BML-275

Formulation:

Crystalline solid

Chemical Name:

6-[4-(2-piperidin-1-ylethoxy)phenyl]-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine

Molecular Formula:

C₂₄H₂₅N₅O

Molecular Weight:

399.5

CAS Number

866405-64-3

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Paul, B. Y., Hong, C. C., Sachidanandan, C., Babitt, J. L., Deng, D. Y., Hoyng, S. A., ... & Peterson, R. T. (2008). Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.Nature chemical biology,4(1), 33-41.

Hao, J., Daleo, M. A., Murphy, C. K., Yu, P. B., Ho, J. N., Hu, J., ... & Hong, C. C. (2008). Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.PloS one,3(8), e2904.

Boergermann, J. H., Kopf, J., Yu, P. B., & Knaus, P. (2010). Dorsomorphin and LDN-193189 inhibit BMP-mediated Smad, p38 and Akt signalling in C2C12 cells.The international journal of biochemistry & cell biology,42(11), 1802-1807.