Applications

FA

Synonyms:

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide, Selisistat, EX527, SIRT1 Inhibitor III

Formulation:

Crystalline solid

Chemical Name:

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide

Molecular Formula:

C₁₃H₁₃ClN₂O

Molecular Weight:

248.7

CAS Number

49843-98-3

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Gertz, M., Fischer, F., Nguyen, G. T. T., Lakshminarasimhan, M., Schutkowski, M., Weyand, M., & Steegborn, C. (2013). Ex-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanism.Proceedings of the National Academy of Sciences,110(30), E2772-E2781.

Solomon, J. M., Pasupuleti, R., Xu, L., McDonagh, T., Curtis, R., DiStefano, P. S., & Huber, L. J. (2006). Inhibition of SIRT1 catalytic activity increases p53 acetylation but does not alter cell survival following DNA damage.Molecular and cellular biology,26(1), 28-38.

Price, N. L., Gomes, A. P., Ling, A. J., Duarte, F. V., Martin-Montalvo, A., North, B. J., ... & Sinclair, D. A. (2012). SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function.Cell metabolism,15(5), 675-690.

Kabra, N., Li, Z., Chen, L., Li, B., Zhang, X., Wang, C., ... & Chen, J. (2009). SirT1 is an inhibitor of proliferation and tumor formation in colon cancer.Journal of Biological Chemistry,284(27), 18210-18217.