IQ-1

2024-10-15

IQ-1

货号:3316280-10,3316280-50

规格:10mg,50mg

价格:1760,7755

产品类型:小分子化合物

品牌:Biogems

Catalogue Number :3316280

Description

IQ-1 is a selective inhibitor of Beta-catenin/p300 signaling by binding to protein phosphatase 2. It is used to maintain embryonic cell pluripotency in Wnt3a-treated cells and prevent spontaneous differentiation. It is also reported to upregulate the expression of Sox2 and Oct4 transcription factors.

Additional Information

Applications

FA

Synonyms:

ST50223451, MLS000559249, AC1NY3UK, CHEMBL3193709

Formulation:

Crystalline solid

Chemical Name:

(2E)-2-[(4-acetylphenyl)hydrazinylidene]-2-(3,3-dimethyl-4H-isoquinolin-1-yl)acetamide

Molecular Formula:

C21H22N4O2

Molecular Weight:

362.4

CAS Number

331001-62-8

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

cMiyabayashi, T., Teo, J. L., Yamamoto, M., McMillan, M., Nguyen, C., & Kahn, M. (2007). Wnt/β-catenin/CBP signaling maintains long-term murine embryonic stem cell pluripotency.Proceedings of the National Academy of Sciences,104(13), 5668-5673.

Chase, L. G., & Firpo, M. T. (2007). Development of serum-free culture systems for human embryonic stem cells.Current opinion in chemical biology,11(4), 367-372.

Miki, T., Yasuda, S. Y., & Kahn, M. (2011). Wnt/β-catenin signaling in embryonic stem cell self-renewal and somatic cell reprogramming.Stem Cell Reviews and Reports,7(4), 836-846.

技术参数
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