Applications

FA

Synonyms:

Inhibitor of Wnt Production-3

Formulation:

Crystalline solid

Chemical Name:

2-[[3-(4-fluorophenyl)-3,4,6,7-tetrahydro-4-oxothieno[3,2-d]pyrimidin-2-yl]thio]-N- (6-methyl-2-benzothiazolyl)-acetamide

Molecular Formula:

C₂₂H₁₇FN₄O₂S₃

Molecular Weight:

484.6

CAS Number

687561-60-0

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Chen, B., Dodge, M. E., Tang, W., Lu, J., Ma, Z., Fan, C. W., ... & Lum, L. (2009). Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer.Nature chemical biology,5(2), 100-107.

Willems, E., Spiering, S., Davidovics, H., Lanier, M., Xia, Z., Dawson, M., ... & Mercola, M. (2011). Small-molecule inhibitors of the Wnt pathway potently promote cardiomyocytes from human embryonic stem cell–derived mesoderm.Circulation research,109(4), 360-364.

Lanier, M., Schade, D., Willems, E., Tsuda, M., Spiering, S., Kalisiak, J., ... & Cashman, J. R. (2012). Wnt inhibition correlates with human embryonic stem cell cardiomyogenesis: a structure–activity relationship study based on inhibitors for the Wnt response.Journal of medicinal chemistry,55(2), 697-708.