Applications

FA

Synonyms:

L-161982, 147776-06-5, CHEMBL1395820

Formulation:

Crystalline solid

Chemical Name:

N-[2-[4-[[3-butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonyl-3-methylthiophene-2-carboxamide

Molecular Formula:

C₃₂H₂₉F₃N₄O₄S₂

Molecular Weight:

654.2

CAS Number

147776-06-5

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Cherukuri, D. P., Chen, X. B., Goulet, A. C., Young, R. N., Han, Y., Heimark, R. L., ... & Nelson, M. A. (2007). The EP4 receptor antagonist, L-161,982, blocks prostaglandin E 2-induced signal transduction and cell proliferation in HCA-7 colon cancer cells.Experimental cell research,313(14), 2969-2979.

Yanni, S. E., Barnett, J. M., Clark, M. L., & Penn, J. S. (2009). The role of PGE2 receptor EP4 in pathologic ocular angiogenesis.Investigative ophthalmology & visual science,50(11), 5479.

Aoudjit, L., Potapov, A., & Takano, T. (2006). Prostaglandin E2 promotes cell survival of glomerular epithelial cells via the EP4 receptor.American Journal of Physiology-Renal Physiology,290(6), F1534-F1542.