Applications

FA

Synonyms:

LY 411575, LY411575, Semagacestat

Formulation:

Crystalline solid

Chemical Name:

(2S)-2-[[(2S)-2-(3,5-difluorophenyl)-2-hydroxyacetyl]amino]-N-[(7S)-5-methyl-6-oxo-7H-benzo[d][1]benzazepin-7-yl]propanamide

Molecular Formula:

C₂₆H₂₃F₂N₃O₄

Molecular Weight:

479.5

CAS Number

209984-57-6

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Wong, G. T., Manfra, D., Poulet, F. M., Zhang, Q., Josien, H., Bara, T., ... & Parker, E. M. (2004). Chronic treatment with the γ-secretase inhibitor LY-411,575 inhibits β-amyloid peptide production and alters lymphopoiesis and intestinal cell differentiation.Journal of Biological Chemistry,279(13), 12876-12882.

Chen, F., Eckman, E. A., & Eckman, C. B. (2006). Reductions in levels of the Alzheimer’s amyloid β peptide after oral administration of ginsenosides.The FASEB Journal,20(8), 1269-1271.

Curry, C. L., Reed, L. L., Golde, T. E., Miele, L., Nickoloff, B. J., & Foreman, K. E. (2005). Gamma secretase inhibitor blocks Notch activation and induces apoptosis in Kaposi's sarcoma tumor cells.Oncogene,24(42), 6333-6344.