Applications

FA

Synonyms:

PD98059, PD-98059, 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one

Formulation:

Crystalline solid

Chemical Name:

2-(2-amino-3-methoxyphenyl)chromen-4-one

Molecular Formula:

C₁₆H₁₃NO₃

Molecular Weight:

267.3

CAS Number

167869-21-8

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Börsch-Haubold, A. G., Pasquet, S., & Watson, S. P. (1998). Direct inhibition of cyclooxygenase-1 and-2 by the kinase inhibitors SB 203580 and PD 98059 SB 203580 also inhibits thromboxane synthase.Journal of Biological Chemistry,273(44), 28766-28772.

Scheid, M. P., Schubert, K. M., & Duronio, V. (1999). Regulation of Bad phosphorylation and association with Bcl-xL by the MAPK/Erk kinase.Journal of Biological Chemistry,274(43), 31108-31113.

Hotokezaka, H., Sakai, E., Kanaoka, K., Saito, K., Matsuo, K. I., Kitaura, H., ... & Nakayama, K. (2002). U0126 and PD98059, specific inhibitors of MEK, accelerate differentiation of RAW264. 7 cells into osteoclast-like cells.Journal of Biological Chemistry,277(49), 47366-47372.

Reiners, J. J., Lee, J. Y., Clift, R. E., Dudley, D. T., & Myrand, S. P. (1998). PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.Molecular pharmacology,53(3), 438-445.