Applications

FA

Synonyms:

pifithrin-mu, 2-phenylacetylenesulfonamide, NSC 303580

Formulation:

Crystalline solid

Chemical Name:

2-phenylethynesulfonamide

Molecular Formula:

C₈H₇NO₂S

Molecular Weight:

181.2

CAS Number

64984-31-2

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Strom, E., Sathe, S., Komarov, P. G., Chernova, O. B., Pavlovska, I., Shyshynova, I., ... & Gudkov, A. V. (2006). Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation.Nature chemical biology,2(9), 474-479.

Leu, J. J., Pimkina, J., Pandey, P., Murphy, M. E., & George, D. L. (2011). HSP70 inhibition by the small-molecule 2-phenylethynesulfonamide impairs protein clearance pathways in tumor cells.Molecular Cancer Research,9(7), 936-947.

Sekihara, K., Harashima, N., Tamaki, Y., Hieda, Y., Uchida, N., Inomata, T., & Harada, M. (2013, September). Antitumor effect induced by combination of radiation with a novel HSP70 inhibitor pifithrin-mu on human prostate cancer. InEUROPEAN JOURNAL OF CANCER(Vol. 49, pp. S232-S233). THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND: ELSEVIER SCI LTD.