Applications

FA

Synonyms:

Avandia, Rosiglizole, rosiglitazona, BRL49653, Gaudil

Formulation:

Crystalline solid

Chemical Name:

5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione

Molecular Formula:

C₁₈H₁₉N₃O₃S

Molecular Weight:

357.4

CAS Number

122320-73-4

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Fryer, L. G., Parbu-Patel, A., & Carling, D. (2002). The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways.Journal of Biological Chemistry,277(28), 25226-25232.

DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators. (2006). Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: a randomised controlled trial.The Lancet,368(9541), 1096-1105.

Wang, C. H., Ciliberti, N., Li, S. H., Szmitko, P. E., Weisel, R. D., Fedak, P. W., ... & Verma, S. (2004). Rosiglitazone facilitates angiogenic progenitor cell differentiation toward endothelial lineage a new paradigm in glitazone pleiotropy.Circulation,109(11), 1392-1400.