Applications

FA

Synonyms:

Vorinostat, Zolinza, suberoylanilide hydroxamic acid, Suberanilohydroxamic acid

Formulation:

Crystalline solid

Chemical Name:

N'-hydroxy-N-phenyloctanediamide

Molecular Formula:

C₁₄H₂₀N₂O₃

Molecular Weight:

264.3

CAS Number

149647-78-9

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Duvic, M., Talpur, R., Ni, X., Zhang, C., Hazarika, P., Kelly, C., ... & Frankel, S. R. (2007). Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL).Blood,109(1), 31-39.

Marks, P. A., & Breslow, R. (2007). Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drug.Nature biotechnology,25(1), 84-90.

Shankar, S., Davis, R., Singh, K. P., Kurzrock, R., Ross, D. D., & Srivastava, R. K. (2009). Suberoylanilide hydroxamic acid (Zolinza/vorinostat) sensitizes TRAIL-resistant breast cancer cells orthotopically implanted in BALB/c nude mice.Molecular cancer therapeutics,8(6), 1596-1605.