Applications

FA

Synonyms:

SB-202190, SB202190, FHPI, 4-[4-(4-Fluorphenyl)-5-(4-pyridinyl)-1H-imidazol-2-yl]phenol

Formulation:

Crystalline solid

Chemical Name:

4-[4-(4-fluorophenyl)-5-pyridin-4-yl-1,3-dihydroimidazol-2-ylidene]cyclohexa-2,5-dien-1-one

Molecular Formula:

C₂₀H₁₄FN₃O

Molecular Weight:

331.3

CAS Number

152121-30-7

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Nemoto, S., Xiang, J., Huang, S., & Lin, A. (1998). Induction of apoptosis by SB202190 through inhibition of p38β mitogen-activated protein kinase.Journal of Biological Chemistry,273(26), 16415-16420.

Manthey, C. L., Wang, S. W., Kinney, S. D., & Yao, Z. (1998). SB202190, a selective inhibitor of p38 mitogen-activated protein kinase, is a powerful regulator of LPS-induced mRNAs in monocytes.Journal of leukocyte biology,64(3), 409-417.

Hirosawa, M., Nakahara, M., Otosaka, R., Imoto, A., Okazaki, T., & Takahashi, S. (2009). The p38 pathway inhibitor SB202190 activates MEK/MAPK to stimulate the growth of leukemia cells.Leukemia research,33(5), 693-699.