Applications

FA

Synonyms:

SB203580, RWJ 64809, CHEMBL10, CTK8E9223

Formulation:

Crystalline solid

Chemical Name:

4-[4-(4-fluorophenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine

Molecular Formula:

C₂₁H₁₆FN₃OS

Molecular Weight:

377.4

CAS Number

152121-47-6

Purity:

≥98%

Storage Conditions:

Product should be kept at -20°C.

References:

Lali, F. V., Hunt, A. E., Turner, S. J., & Foxwell, B. M. (2000). The pyridinyl imidazole inhibitor SB203580 blocks phosphoinositide-dependent protein kinase activity, protein kinase B phosphorylation, and retinoblastoma hyperphosphorylation in interleukin-2-stimulated T cells independently of p38 mitogen-activated protein kinase.Journal of Biological Chemistry,275(10), 7395-7402.

Barancik, M., Htun, P., Strohm, C., Kilian, S., & Schaper, W. (2000). Inhibition of the cardiac p38-MAPK pathway by SB203580 delays ischemic cell death.Journal of cardiovascular pharmacology,35(3), 474-483.

Martin, J. L., Avkiran, M., Quinlan, R. A., Cohen, P., & Marber, M. S. (2001). Antiischemic Effects of SB203580 Are Mediated Through the Inhibition of p38α Mitogen-Activated Protein Kinase Evidence From Ectopic Expression of an Inhibition-Resistant Kinase.Circulation research,89(9), 750-752.