Tamoxifen

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Tamoxifen

货号:1052910-500,1052910-5

规格:500mg,5g

价格:550,4400

产品类型:小分子化合物

品牌:Biogems

Catalogue Number :1052910

Description

Tamoxifen is a modulator of the of the estrogen receptor, with tissue specific agonistic and antagonistic effects. It is metabolized in the liver to 4- hydroxytamoxifen (afimoxifene) and N-desmethyl-4-hydroxytamoxifen (endoxifen), which compete with estrogen for binding to the estrogen receptor. Tamoxifen also has neuroprotective properties in female rats and is reported to block certain cancer cell growth.

Additional Information

Applications

FA

Synonyms:

Crisafenom, Citofen, Nolvadex, Oncomox, Soltamox

Formulation:

Crystalline solid

Chemical Name:

2-[4-[(Z)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethylethanamine

Molecular Formula:

C26H29NO

Molecular Weight:

371.5

CAS Number

10540-29-1

Purity:

≥95%

Storage Conditions:

Product should be kept at -20°C.

References:

Fisher, B., Costantino, J. P., Wickerham, D. L., Redmond, C. K., Kavanah, M., Cronin, W. M., ... & Bowel Project Investigators. (1998). Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study.Journal of the National Cancer Institute,90(18), 1371-1388.

Shiau, A. K., Barstad, D., Loria, P. M., Cheng, L., Kushner, P. J., Agard, D. A., & Greene, G. L. (1998). The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen.Cell,95(7), 927-937.

Kimelberg, H. K., Jin, Y., Charniga, C., & Feustel, P. J. (2003). Neuroprotective activity of tamoxifen in permanent focal ischemia.Journal of neurosurgery,99(1), 138-142.

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