Recombinant Rat IL-21
货号：400-41-10,400-41-100,400-41-1000,400-41-2,400-41-250,400-41-500
规格：10ug,100ug,1mg,2ug,250ug,500ug
价格：1425,11123,44543,585,19450,28897
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：IL‐21 is a pleiotropic cytokine produced by CD4+ T cells in response to antigenic stimulation. Its action generally enhances antigen‐specific responses of immune cells. The biological effects of IL‐21 include: inducing the differentiation of T cell‐stimulated B cells into plasma cells and memory B cells; the stimulation of IgG production in conjunction with IL‐4; and the induction of apoptotic effects in naïve B cells and stimulated B cells in the absence of T cell signaling. Additionally, IL‐21 promotes the anti‐tumor activity of CD8+ T cells and NK cells. IL‐21 exerts its effect through binding to a specific type I cytokine receptor, IL‐21R, which also contains the γ chain (γc) found in other cytokine receptors, including IL‐2, IL‐4, IL‐7, IL‐9 and IL‐15. The IL‐21/IL‐21R interaction triggers a cascade of events, which includes activation of the tyrosine kinases JAK1 and JAK3, followed by activation of the transcription factors STAT1 and STAT3. Recombinant Rat IL‐21 is a 15.3 kDa protein containing 130 amino acid residues.来源:E.coli别名:Interleukin-21氨基酸序列:MHKSSPQRPD HLLIRLRHLM DIVEQLKIYE NDLDPELLTA PQDVKGQCEH EAFACFQKAK LKPSNTGNNK TFINDLLAQL RRRLPAKRTG NKQRHMAKCP SCDLYEKKTP KEFLERLKWL LQKMIHQHLS纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to stimulate the proliferation of human ANBL-6 cells. The expectedED50is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106units/mg.Calculated Molecular Weight:15.3 kDaAccession Number:A3QPB9Gene ID:365769原产地:USA仅用于科研，不能用于临床和诊断。 |
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