Recombinant Human/Murine/Rat GDF-11
货号：120-11-5,120-11-100,120-11-1000,120-11-20,120-11-250,120-11-50,120-11-500
规格：5ug,100ug,1mg,20ug,250ug,50ug,500ug
价格：640,9126,36565,1560,15974,5475,23727
产品类型：细胞因子添加物
品牌：PeproTech
| 产品详情产品编号：120-11产品描述：GDF-11 is a myostatin-homologous protein that acts as an inhibitor of nerve tissue growth. GDF-11 has been shown to suppress neurogenesis through a myostatin-like pathway, which involves the arrest of the progenitor cell cycle in the G1 phase. Similarities between myostatin and GDF-11, which are 90% identical in their amino acid sequence, suggest that the regulatory mechanisms responsible for maintaining proper tissue size during neural and muscular development might be the same. Recombinant Human/Murine/Rat GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8, sharing 90% amino acid sequence identity.Source:E.coliSynonyms:Growth/Differentiation Factor-11, BMP-11AA Sequence (monomer):NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCSPurity:≥ 98% by SDS-PAGE gel and HPLC analyses.Biological Activity:Assay #1:Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expectedED50for this effect is 0.08-0.10 µg/ml.Assay #2:Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1cells. TheED50for this effect is 8-10 ng/ml.Calculated Molecular Weight:25 kDaAccession Number:O95390Gene ID:10220Note:1mg will be provided as 2x500μg.crossreactivity:Human,Mouse,RatCountry Of Origin:USANot for human use. |
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