Recombinant Human Gremlin-1

货号：120-42-10,120-42-100,120-42-1000,120-42-250,120-42-50,120-42-500

规格：10ug,100ug,1mg,250ug,50ug,500ug

价格：585,3202,12850,5608,1425,8332

产品类型：细胞因子添加物

品牌：PeproTech

产品描述：Gremlin-1 (isoform-1) belongs to a group of diffusible proteins that bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Gremlin-1 is highly expressed in the small intestine, fetal brain, and colon; and is expressed at lower levels in the brain, prostate, pancreas, and in skeletal muscle. Gremlin-1 regulates multiple functions in early development by specifically binding to, and inhibiting the function of, BMP-2, -4, and -7. It also plays a role in carcinogenesis and kidney branching morphogenesis. Recombinant Human Gremlin-1 is a 18.3 kDa protein containing 160 amino acid residues.来源:CHO cells

别名:CKTSF1B1, DAND2, DRM, IHG-2

氨基酸序列:KKKGSQGAIP PPDKAQHNDS EQTQSPQQPG SRNRGRGQGR GTAMPGEEVL ESSQEALHVT ERKYLKRDWC KTQPLKQTIH EEGCNSRTII NRFCYGQCNS FYIPRHIRKE EGSFQSCSFC KPKKFTTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD

纯度:≥ 90% by SDS-PAGE gel and HPLC analyses.

Biological Activity:Determined by its ability to inhibit BMP-4 induced alkaline phosphatase production by ATDC-5 chondrogenic cells. TheED50for this effect is 0.07-0.11 μg/ml.

Calculated Molecular Weight:18.3 kDa

Accession Number:O60565

Gene ID:26585

交叉反应:Human

技术参数

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