Thiazovivin
货号：04-0017
规格：1 mg
价格：0
产品类型：小分子化合物
品牌：Stemgent
Thiazovivin is a selective, cell permeable small molecule that directly targets Rho-associated kinase (ROCK)1. In addition, Thiazovivin protects human embryonic stem cells (hESCs) in the absence of ECM by regulating E-cadherin mediated cell-cell interaction1. This observation suggests that Thiazovivin promotes cell survival. In other studies Thiazovivin, in combination with inhibitors of the TGF-β receptor and MEK pathway, hasshown to improve reprogramming efficiency by more than 200-fold2.
产品详情
| Size | 1 mg |
| ChemicalName | N-benzyl-2-(pyrimidin-4-ylamino)thiazole-4-carboxamide |
| Chemical Formula | C15H13N5OS |
| Molecular Weight | 311.36 |
| CAS Number | 1226056-71-8 |
| Purity | Greater than 98% by HPLC analysis |
| Formulation | Light brown powder |
| Solubility | For a 10 mM concentrated stock solution of Thiazovivin, reconstitute the compound by adding 321.2 μl of DMSO to the entire contents of the vial. If precipitate is observed, warm the solution to 37°C for 2 to 5 minutes. For use in cell culture, warm the medium just prior to adding the reconstituted compound. Once the compound is added, mix and filter-sterilize the medium using a 0.2 µM low-protein binding filter. Thiazovivin is soluble in DMSO at 100 mM. |
| Storage and Stability | Store powder at 4°C protected from light. Following reconstitution, store aliquots at -20°C. Stock solutions are stable for 6 months when stored as directed. |
| Quality Control | The purity of Thiazovivin was determined by HPLC analysis. The accurate mass was determined by mass spectrometry. No acute cytotoxicity was observed in mouse embryonic stem cells following a 6 hour exposure to 1 nM - 100 µM ofThiazovivin. |
参考文献
Xu, Y., Zhu, X., Hahm, H.S., Wei, W., Hao, E., Hayek, A., and Ding, S. (2010) Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules. Proc Natl Acad Sci USA 107: 8129-8134.
Lin, T., Ambasudhan, R., Yuan, X., Li, W., Hilcove, S., Abujarour, R., Lin, X., Hahm, H.S., Hao, E., Hayek, A., and Ding, S. (2009) A chemical platform for improved induction of human iPSCs. Nat Methods 6: 805-808.
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