Animal-Free Recombinant Murine TNF-α

货号：AF-315-01A-5,AF-315-01A-1000,AF-315-01A-20,AF-315-01A-250,AF-315-01A-5,AF-315-01A-50,AF-315-01A-500

规格：100ug,1mg,20ug,250ug,5ug,50ug,500ug

价格：12700,50820,2830,22230,1250,7620,33030

产品类型：细胞因子添加物

品牌：PeproTech

产品描述：TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-α demonstrate significant cross-species reactivity. TNF-α exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-α transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-α, which forms a non-covalently linked homotrimer in solution. Recombinant Murine TNF-α is a soluble 157 amino acid protein (17.3 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.Manufactured using all Animal-Free reagents.来源:E.coli别名:Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin氨基酸序列:MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by the cytolysis of murine L929 cells in the presence of Actinomyocin D. The expectedED₅₀is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 10⁷units/mg.Calculated Molecular Weight:17.3 kDaAccession Number:P06804Gene ID:21926交叉反应:Mouse

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