Animal-Free Recombinant Human TGF-β1 (CHO cell derived)
货号：AF-100-21C-10,AF-100-21C-100,AF-100-21C-1000,AF-100-21C-2,AF-100-21C-250,AF-100-21C-50,AF-100-21C-500
规格：10ug,100ug,1mg,2ug,250ug,50ug,500ug
价格：1778,13830,53444,791,23339,8304,34670
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：The three mammalian isoforms of TGF-β, TGF-β1, β2, and β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility, as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes, including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes, which are stored at the cell surface and in the extracellular matrix. The release of the biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and/or induction of conformational changes by proteins such as thrombospondin-1. TGF-b1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts, and recently it has been implicated in the formation of skin tumors. Recombinant Human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.Manufactured using all Animal-Free reagents.来源:CHO cells别名:Transforming Growth Factor-β1, Differentiation inhibiting factor, Cartilage-inducing factor氨基酸序列:ALDTNYCFSS TEKNCCVRQL YIDFRKDLGW KWIHEPKGYH ANFCLGPCPY IWSLDTQYSK VLALYNQHNP GASAAPCCVP QALEPLPIVY YVGRKPKVEQ LSNMIVRSCK CS纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells. The expectedED50is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.Calculated Molecular Weight:25 kDaAccession Number:P01137Gene ID:7040Note:1mg will be provided as 2x500μg.交叉反应: Human,Mouse,Pig |
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