Recombinant Human sRANK Receptor
货号：310-08-100,310-08-1000,310-08-20,310-08-250,310-08-500
规格：100ug,1mg,20ug,250ug,500ug
价格：1425,9425,585,4112,6112
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：RANKL and RANK are members of the TNF superfamily of ligands and receptors that play an important role in the regulation of specific immunity and bone turnover. RANK (receptor) was originally identified as a dendritic cell-membrane protein, which, by interacting with RANKL, augments the ability of dendritic. These dendritic cells then stimulate naïve T-cell proliferation, and promote the survival of RANK + T-cells. RANK is also expressed in a variety of tissues, including skeletal muscle, thymus, liver, colon, small intestine, and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis, and in dendritic cell-mediated T-cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget's disease of bone (PDB2). Recombinant Human sRANK Receptor is a 19.3 kDa polypeptide containing the TNFR-homologous, cysteine-rich portion of the extracellular domain of RANK receptor (175 amino acid residues).来源:E.coli别名:TNFRSF11A, ODFR (osteoclast differentiation factor receptor), ODAR (osteoclast differentiation and activation receptor), TRANCE Receptor氨基酸序列:MQIAPPCTSE KHYEHLGRCC NKCEPGKYMS SKCTTTSDSV CLPCGPDEYL DSWNEEDKCL LHKVCDTGKA LVAVVAGNST TPRRCACTAG YHWSQDCECC RRNTECAPGL GAQHPLQLNK DTVCKPCLAG YFSDAFSSTD KCRPWTNCTF LGKRVEHHGT EKSDAVCSSS LPARK纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by its ability to inhibit sRANKL induced NF-κB in RAW264.7 cells in the absence of any cross-linking. The expectedED50for this effect in the presence of 15 ng/ml of recombinant sRANKL, is 30-50 ng/ml.Calculated Molecular Weight:19.3 kDaAccession Number:Q9Y6Q6Gene ID:8792交叉反应：Human,Mouse原产国:USA |
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