CD4 Monoclonal Antibody (N1UG0), Biotin
货号：13-2444-82
规格：100 µg
价格：2340
产品类型：流式抗体
品牌：Thermo Fisher
物种：人
宿主：小鼠
抗体亚型：IgG2b, kappa
荧光染料：Biotin
| 抗体类型 | 单抗 | 同型对照： | Mouse IgG2b kappa Isotype Control (eBMG2b), Biotin |
| 浓度： | 0.5 mg/mL | 用法： | 10 µg/mL (IHC (P))；0.25 µg/test (Flow) |
| 产品详细信息Description: The N1UG0 monoclonal antibody reacts with human CD4, a 59 kDa cell surface glycoprotein expressed by the majority of thymocytes, a subpopulation of mature T cells (T-helper cells) and in low levels on monocytes. CD4 is a receptor for the human immunodeficiency virus (HIV). The N1UG0 antibody is recommended for use in staining human formalin-fixed paraffin embedded tissue sections.Applications Reported: This N1UG0 antibody has been reported for use in flow cytometric analysis, western blotting, and immunohistochemical staining of formalin-fixed paraffin embedded tissue sections.Applications Tested: This N1UG0 antibody has been tested by immunohistochemistry of formalin-fixed paraffin embedded human tissue using low or high pH antigen retrieval and can be used at less than or equal to 10 µg/mL. The N1UG0 antibody has been tested by flow cytometric analysis of human PBMC. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Filtration: 0.2 µm post-manufacturing filtered.靶标信息The CD4 antigen is involved in the recognition of MHC class II molecules and is a co-receptor for HIV. CD4 is primarily expressed in a subset of T-lymphocytes, also referred to as T helper cells, but may also be expressed by other cells in the immune system, such as monocytes, macrophages, and dendritic cells. At the tissue level, CD4 expression may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues. CD4 functions to initiate or augment the early phase of T-cell activation through its association with the T-cell receptor complex and protein tyrosine kinase, Lck. It may also function as an important mediator of direct neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcripts have been identified in this gene [RefSeq, July 2017]. |
| 数据 |
| CD4 Antibody (13-2444-82) in IHCImmunohistochemistry of formalin-fixed paraffin embedded human tonsil using 10 µg/mL of Anti-Human CD4 Biotin, followed by Streptavidin HRP, and DAB visualization. Nuclei are counterstained with hematoxylin. |
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| 参考文献： |
| 1.eLifeHighly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes."Published figure using CD4 monoclonal antibody (Product # 13-2444-82) in Immunofluorescence"2.eLifeHighly multiplexed immunofluorescence imaging of human tissues and tumors using t-CyCIF and conventional optical microscopes."Published figure using CD4 monoclonal antibody (Product # 13-2444-82) in Immunofluorescence" |
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