Recombinant Human sFas Ligand
货号：310-03H-10,310-03H-100,310-03H-1000,310-03H-2,310-03H-250,310-03H-500
规格：10ug,100ug,1mg,2ug,250ug,500ug
价格：1418,9146,36654,582,16005,23780
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述:Fas Ligand (FasL) is a member of the TNF superfamily that is expressed on the cell surface of activated T cells. Binding of FasL to Fas Receptor triggers apoptosis in Fas-bearing cells. FasL has the ability to kill T cells and activated B cells, which leads to down-regulation of the immune response. The mechanism of Fas-induced apoptosis involves recruitment of pro-caspase 8 through an adaptor molecule called FADD, followed by processing of the pro-enzyme into active forms. These active caspases then cleave various cellular substrates, leading to the eventual cell death. Both human and murine sFasL are fully active on human and murine cells. Recombinant Human soluble Fas Ligand is a 17.9 kDa protein comprising the TNF-homologous region of FasL and contains an 8-residue N-terminal His-Tag.别名:soluble Fas Ligand (sFasL), TNFSF6, CD95L, Apo I Ligand, APTL氨基酸序列:HHHHHHHHPS PPPEKKELRK VAHLTGKSNS RSMPLEWEDT YGIVLLSGVK YKKGGLVINE TGLYFVYSKV YFRGQSCNNL PLSHKVYMRN SKYPQDLVMM EGKMMSYCTT GQMWARSSYL GAVFNLTSAD HLYVNVSELS LVNFEESQTF FGLYKL来源:CHO cells纯度:Greater than 95% by SDS-PAGE gel and HPLC analyses.生物活性:Determined by it's ability to induce cytotoxicity in Jurkat cells in the absence of any cross-linking. TheED50for this effect is ≤ 10.0 ng/ml, corresponding to a specific activity of ≥ 1 x 105units/mg.Calculated Molecular Weight:17.9 kDaAccession Number:P48023Gene ID:356交叉反应:Mouse, Human, N/A原产地:USA仅用于科研，不能用于临床和诊断。 |
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