Anti-Mouse B7-H4 SAFIRE Purified

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Anti-Mouse B7-H4 SAFIRE Purified

货号:86612-25

规格:50 μg

价格:2019

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :86612-25

Description

The 188 monoclonal antibody binds to mouse B7-H4, a newly discovered member of the B7 family involved with the negative regulation of T cell immunity. B7-H4 is a type I membrane glycoprotein also known as B7S1, B7X, and VCTN1. Its role in tumor progression may be to protect precancerous cells from the surveillance of the immune system. Further studies are being conducted to determine the exact B7-H4 ligand. It is reported that the H74 antibody binds to mouse B7-H4 transfected cells and not spleen cells.

Additional Information

Clone

188

Format:

SAFIRE Purified

Applications

FC, FA

Reactivity

Mouse

Isotype:

Rat IgG2b, kappa

Research Interest:Adaptive Immunity

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Yi, K. H., & Chen, L. (2009). Fine tuning the immune response through B7‐H3 and B7‐H4.Immunological reviews,229(1), 145-151.

Chen, Y., Yang, C., Xie, Z., Zou, L., Ruan, Z., Zhang, X., ... & Wu, Y. (2006). Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells.Kidney international,70(12), 2092-2099.

Kamimura, Y., Kobori, H., Piao, J., Hashiguchi, M., Matsumoto, K., Hirose, S., & Azuma, M. (2009). Possible involvement of soluble B7-H4 in T cell-mediated inflammatory immune responses.Biochemical and biophysical research communications,389(2), 349-353.

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