Anti-Human TIM3 APC

2024-10-15

Anti-Human TIM3 APC

货号:78211-80-25,78211-80-100

规格:25 tests,100 tests

价格:1430,3740

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :78211-80

Description

The F38-2E2 monoclonal antibody specifically reacts with human T cell immunoglobulin and mucin domain containing protein (TIM3), a transmembrane molecule found on monocytes, macrophages, dendritic cells, and activated T cell types such as Treg, Th1, and Th17. TIM3 can exist in soluble and membrane bound forms and the relevant ligand for the protein is Galectin-9. It plays a role in the creation of immunological tolerances, the secretion of Th1 and Th17 related cytokines, and HIV infection.

Additional Information

Clone

F38-2E2

Format:

APC

Applications

FC

Reactivity

Human

Isotype:

Mouse IgG1, kappa

Research Interest:Adaptive Immunity
Cell Type:Th1 cells,Monocytes and Macrophages,Treg cells, Th17 cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Klibi, J., Niki, T., Riedel, A., Pioche-Durieu, C., Souquere, S., Rubinstein, E., ... & Busson, P. (2009). Blood diffusion and Th1-suppressive effects of galectin-9–containing exosomes released by Epstein-Barr virus–infected nasopharyngeal carcinoma cells.Blood,113(9), 1957-1966.

Hastings, W. D., Anderson, D. E., Kassam, N., Koguchi, K., Greenfield, E. A., Kent, S. C., ... & Kuchroo, V. K. (2009). TIM‐3 is expressed on activated human CD4+ T cells and regulates Th1 and Th17 cytokines.European journal of immunology,39(9), 2492-2501.

Koguchi, K., Anderson, D. E., Yang, L., O'Connor, K. C., Kuchroo, V. K., & Hafler, D. A. (2006). Dysregulated T cell expression of TIM3 in multiple sclerosis.The Journal of experimental medicine,203(6), 1413-1418.

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