Anti-Mouse/Rat IL-17A FITC

admin 2024-10-15 12

Anti-Mouse/Rat IL-17A FITC

货号:73812-50-25,73812-50-100

规格:25 tests,100 tests

价格:1131,2389

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :73812-50

Description

The 17B7 monoclonal antibody specifically binds to mouse and rat IL-17A, a pro-inflammatory cytokine. It is produced by T helper 17 (Th17) cells, a unique subset of IL-23 dependent CD4+ T cells. Interleukin-17A is highly expressed in transplant rejection, asthma, psoriasis, and multiple sclerosis, and enhances the expression of ICAM-1 in human fibroblasts. The homodimer is expressed by activated peripheral CD4+ T lymphocytes. The Interleukin-17A binds to the IL-17 receptors (IL-17R) expressed by mast cells, monocytes and macrophages, fibroblasts, and endothelial and epithelial cells.

Additional Information

Clone

17B7

Format:

FITC

Applications

FC

Reactivity

Mouse, Rat

Isotype:

Rat IgG2a, kappa

Research Interest:Adaptive Immunity, Cytokines & Growth Factors
Cell Type:T Cells, Th17 cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Wu, S., Rhee, K. J., Albesiano, E., Rabizadeh, S., Wu, X., Yen, H. R., ... & Sears, C. L. (2009). A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses.Nature medicine,15(9), 1016-1022.

Cao, H., Lan, Q., Shi, Q., Zhou, X., Liu, G., Liu, J., ... & Liu, Z. (2011). Anti-IL-23 antibody blockade of IL-23/IL-17 pathway attenuates airway obliteration in rat orthotopic tracheal transplantation.International immunopharmacology,11(5), 569-575.

Yan, S., Wang, L., Liu, N., Wang, Y., & Chu, Y. (2012). Critical role of interleukin-17/interleukin-17 receptor axis in mediating Con A-induced hepatitis.Immunology and cell biology,90(4), 421-428.

技术参数
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