Anti-Mouse CD70 SAFIRE Purified

admin 2024-10-16 20

Anti-Mouse CD70 SAFIRE Purified

货号:02812-25-50,02812-25-100,02812-25-500

规格:50 ug,100 ug,500 ug

价格:1100,1815,3630

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :02812-25

Description

The FR70 monoclonal antibody specifically binds to mouse CD70, a 30-33 kDA type II transmembrane protein and member of the TNF superfamily. CD70 is the ligand for CD27 and is expressed on dendritic cells, activated B cell, and a subset of activated T cells at lower levels. Its main role is in regulating B cell activation and immunoglobulin synthesis. CD70 expressing cells are able to co-stimulate T cell proliferation and upregulate cytokine production. The FR70 antibody is reported to block the binding of CD70 to CD27.

Additional Information

Clone

FR70

Format:

SAFIRE Purified

Applications

FC, FA

Reactivity

Mouse

Isotype:

Rat IgG2b, kappa

Research Interest:Adaptive Immunity
Cell Type:B Cells,T Cells,Dendritic Cells

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography. The endotoxin level is determined by LAL test to be less than 0.01 EU/µg of the protein.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Tesselaar, K., Gravestein, L. A., Van Schijndel, G. M., Borst, J., & Van Lier, R. A. (1997). Characterization of murine CD70, the ligand of the TNF receptor family member CD27.The Journal of Immunology,159(10), 4959-4965.

Oshima, H., Nakano, H., Nohara, C., Kobata, T., Nakajima, A., Jenkins, N. A., ... & Okumura, K. (1998). Characterization of murine CD70 by molecular cloning and mAb.International immunology,10(4), 517-526.

Bullock, T. N., & Yagita, H. (2005). Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8+ T cell responses in the absence of CD4+ T cells.The Journal of Immunology,174(2), 710-717.

技术参数
© Bio-Rad伯乐代理官网-伯乐抗体-伯乐层析Aminex色谱柱是专业的授权总代理区域代理经销平台。
© 如需询价,请加客服QQ:1749072012 、客服微信:jinshanbio,或发送邮件到1749072012@qq.com
© 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务,数据资源基于CC协议。
© 本文地址:https://biorod.cn/thread-15620.htm
产品询价需求提交
最新回复 (0)
返回
发布信息
扫码添加客服微信,咨询产品报价