Anti-Mouse/Rat CD40 FITC

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Anti-Mouse/Rat CD40 FITC

货号:02512-50-1,02512-50-100,02512-50-50,02512-50-500

规格:1 mg,100 μg,50 μg,500 μg

价格:5940,1980,1100,3630

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:FITC

Catalogue Number :02512-50

Description

The HM40-3 monoclonal antibody reacts with mouse CD40, a 48kDA type I glycoprotein known as Bp50. CD40 is part of the TNFR family and expressed on a subset of T cells, B cells, dendritic cells, and macrophages. It has been shown to be involved in the protection of B cells from apoptosis, B cell differentiation, co-stimulation, and isotype class-switching. The HM40-3 antibody blocks the binding of CD40L (CD154) and stimulates B and dendritic cell proliferation.

Additional Information

Clone

HM40-3

Format:

FITC

Applications

FC

Reactivity

Mouse, Rat

Isotype:

Armenian Hamster IgM, kappa

Research Interest:Adaptive Immunity
Cell Type:B Cells,Monocytes and Macrophages,NK and NKT Cells,Dendritic Cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Kaneko, Y., Hirose, S., Abe, M., Yagita, H., Okumura, K., & Shirai, T. (1996). CD40‐mediated stimulation of B1 and B2 cells: implication in autoantibody production in murine lupus.European journal of immunology,26(12), 3061-3065.

Ferlin, W. G., Severinson, E., Ström, L., Heath, A. W., Coffman, R. L., Ferrick, D. A., & Howard, M. C. (1996). CD40 signaling induces interleukin‐4‐independent IgE switching in vivo.European journal of immunology,26(12), 2911-2915.

Kashiwada, M., Kaneko, Y., Yagita, H., Okumura, K., & Takemori, T. (1996). Activation of mitogen‐activated protein kinases via CD40 is distinct from that stimulated by surface IgM on B cells.European journal of immunology,26(7), 1451-1458.

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