Anti-Mouse CD152 (CTLA-4) PE-Cy7

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Anti-Mouse CD152 (CTLA-4) PE-Cy7

货号:14612-77-25,14612-77-100

规格:25 μg,100 μg

价格:1084,2593

产品类型:流式抗体

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :14612-77

Description

The UC10-4F10-11 monoclonal antibody specifically reacts with the mouse Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4), also known as CD152. It is a protein with a structure similar to CD28 regarding the genomic organization, amino acid sequence, and structure. CTLA-4 is expressed on activated T cells and CD25+/CD4+ Treg lymphocytes and binds the members of the B7 family, B7-1 (CD80) and B7-2 (CD86), with higher affinity than CD28. CD28 seems to provide opposing signal to T lymphocytes, while CD152 inhibits the T lymphocytes progression to an activated state and their proliferation, CD28 is a costimulator.

The mouse UC10 -4F10-11 monoclonal antibody does not cross-react with the rat leukocytes.

Additional Information

Clone

UC10-4F10-11

Format:

PE-Cyanine7

Applications

FC

Reactivity

Mouse

Isotype:

Armenian Hamster IgG

Research Interest:Adaptive Immunity
Cell Type:T Cells,Treg cells

Preperation:

The product should be stored undiluted at 4°C and should be protected from prolonged exposure to light. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography and unreacted dye was removed from the product.

Formulation:

Phosphate-buffered aqueous solution, ≤0.09% Sodium azide, may contain carrier protein/stabilizer, ph7.2.

References:

Alegre, M. L., Noel, P. J., Eisfelder, B. J., Chuang, E., Clark, M. R., Reiner, S. L., & Thompson, C. B. (1996). Regulation of surface and intracellular expression of CTLA4 on mouse T cells.The Journal of Immunology,157(11), 4762-4770.

Walunas, T. L., Lenschow, D. J., Bakker, C. Y., Linsley, P. S., Freeman, G. J., Green, J. M., ... & Bluestone, J. A. (1994). CTLA-4 can function as a negative regulator of T cell activation.Immunity,1(5), 405-413.

Cilio, C. M., Daws, M. R., Malashicheva, A., Sentman, C. L., & Holmberg, D. (1998). Cytotoxic T Lymphocyte Antigen 4 Is Induced in the Thymus upon In Vivo Activation and Its Blockade Prevents Anti-CD3–mediated Depletion of Thymocytes.The Journal of experimental medicine,188(7), 1239-1246.

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