Anti-Mouse CD122 SAFIRE Purified

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Anti-Mouse CD122 SAFIRE Purified

货号:14312-25-50,14312-25-100

规格:50 ug,100 ug

价格:1320,1925

产品类型:抗体和染料

品牌:Biogems

物种:人

宿主:小鼠

抗体亚型:IgG

荧光染料:Purified

Catalogue Number :14312-25

Description

The TM-beta1 monoclonal antibody specifically reacts with mouse CD122, a beta chain shared by the IL-2 and IL-15 receptors. It is expressed by B cells, T cells, and NK cells and can be used as a marker for NK-cell progenitors. CD122 forms complexes involved in immunoregulation and signal transduction. The TM-beta1 antibody is reported to block the binding of IL-2 and IL-15 to the IL-2 beta receptor.

Additional Information

Clone

TM-beta1

Format:

SAFIRE Purified

Applications

FC, FA

Reactivity

Mouse

Isotype:

Rat IgG2b

Cell Type:T Cells,NK and NKT Cells,B Cells

Preperation:

The product should be stored undiluted at 4°C. Do not freeze. The monoclonal antibody was purified utilizing affinity chromatography.

Formulation:

Phosphate-buffered aqueous solution, ph7.2.

References:

Alleva, D. G., Kaser, S. B., Monroy, M. A., Fenton, M. J., & Beller, D. I. (1997). IL-15 functions as a potent autocrine regulator of macrophage proinflammatory cytokine production: evidence for differential receptor subunit utilization associated with stimulation or inhibition.The Journal of Immunology,159(6), 2941-2951.

Suzuki, H., Kundig, T. M., Furlonger, C., Wakeham, A., Timms, E., Matsuyama, T., ... & Griesser, H. (1995). Deregulated T cell activation and autoimmunity in mice lacking interleukin-2 receptor beta.Science,268(5216), 1472-1476.

Takeuchi, Y., Tanaka, T., Hamamura, K., Sugimoto, T., Miyasaka, M., Yagita, H., & Okumura, K. (1992). Expression and role of interleukin‐2 receptor β chain on CD4− CD8+ T cell receptor αβ+ cells.European journal of immunology,22(11), 2929-2935.

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