Recombinant Human TNF-α
货号：300-01A-10,300-01A-100,300-01A-1000,300-01A-250,300-01A-50,300-01A-500
规格：10ug,100ug,1mg,250ug,50ug,500ug
价格：582,3187,12787,5581,1418,8292
产品类型：细胞因子添加物
品牌：PeproTech
| 产品描述：TNF-α is a pleiotropic pro-inflammatory cytokine secreted by various cells, including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands, and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells, and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, autoimmune diseases, rheumatoid arthritis, inflammation, and diabetes. Human and murine TNF-α demonstrate significant cross-species reactivity. TNF-α exists in two forms; a type II transmembrane protein, and a mature soluble protein. The TNF-α transmembrane protein is proteolitically cleaved to yield a soluble, biologically active, 17 kDa TNF-α, which forms a non-covalently linked homotrimer in solution. Recombinant Human TNF-α is a soluble 157 amino acid protein (17.4 kDa) which corresponds to C-terminal extracellular domain of the full length transmembrane protein.来源:E.coli别名:Tumor Necrosis Factor, TNFSF2, Cachectin, Differentiation-inducing factor (DIF), Necrosin, Cytotoxin氨基酸序列:VRSSSRTPSD KPVAHVVANP QAEGQLQWLN RRANALLANG VELRDNQLVV PSEGLYLIYS QVLFKGQGCP STHVLLTHTI SRIAVSYQTK VNLLSAIKSP CQRETPEGAE AKPWYEPIYL GGVFQLEKGD RLSAEINRPD YLDFAESGQV YFGIIAL纯度:≥ 98% by SDS-PAGE gel and HPLC analyses.生物活性:TheED50as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107units/mg.Calculated Molecular Weight:17.4 kDaAccession Number:P01375Gene ID:7124交叉反应:Bacteria,Cow,Dog,Human,Human + Hamster,Human + Mouse,Human + Rat,Human + Virus,Monkey,Mouse,Pig,Rat,Sheep原产地:USA仅用于科研，不能用于临床和诊断。 |
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