Anti-Human CD4 Antibody, Clone OKT4
货号：60016AZ.1,60016AZ
规格：25 tests,100 tests
价格：1052,1934
产品类型：细胞生物学
品牌：STEMCELL Technologies
类型: | 一抗 | 同型对照： | IgG2b, kappa |
浓度： | | 用法： | 5 μL/ 1 x 10e6细胞 （流式） |
The OKT4 antibody reacts with CD4, an ~59 kDa single-chain type 1 transmembrane glycoprotein and member of the immunoglobulin (Ig) superfamily; CD4 contains four extracellular Ig-like domains (D1 - D4). The epitope for OKT4 has been localized to the D3 domain of the protein, which has a structure resembling an Ig variable domain. CD4 is expressed at relatively high levels by most thymocytes and a subpopulation of T cells (T-helper cells), and at lower levels by peripheral blood monocytes and macrophages. CD4 binds to a non-polymorphic region of MHC II and acts as a co-receptor to the T cell receptor (TCR) in MHC II-restricted antigen recognition by enhancing the affinity of the association between the TCR and MHC II-antigen complex. CD4 also functions to amplify signals from the TCR to the cytoplasm through the interaction of its intracellular domain with cytoplasmic tyrosine kinases such as Lck. Moreover, CD4 is a receptor for human immunodeficiency virus (HIV). Binding of the OKT4 antibody to CD4 does not block HIV binding.This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Direct Human CD4+ T Cell Isolation Kit (Catalog #19662), EasySep™ Human CD4+ T Cell Enrichment Kit (Catalog #19052), EasySep™ Human CD3 Positive Selection Kit II (Catalog #17851) and EasySep™ Human CD4 Positive Selection Kit II (Catalog #17852).
数据 |
| 图1. APC标记的抗体流式图(A) 用APC标记人CD4抗体和FITC标记人CD45抗体，克隆号HI30 (货号 #60018FI)分析人PBMC流式图。(B) 用APC标记的小鼠 IgG2b, kappa同型, Clone MPC-11, (货号 #60072AZ)和FITC标记的人CD45抗体，克隆号 HI30分析人 PBMC的流式图。 |
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