ANTI-HUMAN CD38 (HIT2) FITC

货号：11-0389-41,11-0389-42

规格：25TESTS,100TESTS

价格：835,1004

产品类型：流式抗体

品牌：eBioscience

抗原：CD38

物种：人

宿主：小鼠

抗体亚型：IgG

克隆号：HIT2

荧光染料：FITC

类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC
浓度：	5 µL/Test	用法：	5uL（1 µg）/test(Flow）

产品详细信息Description: The HIT2 monoclonal antibody reacts with the human CD38 molecule, an approximately 45 kDa type II transmembrane protein. CD38 is expressed by thymocytes, peripheral B cells including plasma cells, activated T cells, and monocytes. CD38 is a counter-receptor for CD31 and has both cyclase and hydrolase enzymatic activity.Applications Reported: The HIT2 antibody has been reported for use in flow cytometric analysis.Applications Tested: The HIT2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD38 (NAD+ glycohydrolase) is a type II transmembrane glycoprotein able to induce activation, proliferation and differentiation of mature lymphocytes and mediate apoptosis of myeloid and lymphoid progenitor cells. CD38 functions as a multi-catalytic ectoenzyme serving as ADP-ribosyl cyclase, cyclic ADP-ribose hydrolase and possibly NAD+ glycohydrolase or as a cell surface receptor. Antibodies to CD38 are useful in subtyping of lymphomas and leukemias, detection of plasma cells (i.e. identification of myelomas), and as a marker for activated B and T cells. CD38 participates in cell adhesion, signal transduction and calcium signaling. Further, CD38 is expressed at high levels in the pancreas, liver, kidney, malignant lymphoma and neuroblastoma. Diseases associated with CD38 dysfunction include chronic lymphocytic leukemia and Richter's Syndrome.

数据

CD38 Antibody (11-0389-41) in FlowStaining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (blue histogram) or Anti-Human CD38 FITC (purple histogram). Cells in the lymphocyte gate (left) and monocyte gate (right) were used for analysis.

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参考文献：

1.Journal of immunology (Baltimore, Md. : 1950)The upregulation of LAG-3 on T cells defines a subpopulation with functional exhaustion and correlates with disease progression in HIV-infected subjects."11-0389 was used in Flow cytometry/Cell sorting to study the role of LAG-3 on T cell functionality during persistent HIV-1 infection."Authors Tian X,Zhang A,Qiu C,Wang W,Yang Y,Qiu C,Liu A,Zhu L,Yuan S,Hu H,Wang W,Wei Q,Zhang X,Xu J2.PloS oneIncomplete normalization of regulatory t-cell frequency in the gut mucosa of Colombian HIV-infected patients receiving long-term antiretroviral treatment."11-0389 was used in Flow cytometry/Cell sorting to assess the frequency and phenotype of regulatory T-cells within CMV and HIV patients on different treatment regimes."Authors Rueda CM,Velilla PA,Chougnet CA,Rugeles MT3.AIDS (London, England)CD4⁺CD73⁺ T cells are associated with lower T-cell activation and C reactive protein levels and are depleted in HIV-1 infection regardless of viral suppression."11-0389 was used in Flow cytometry/Cell sorting to assess suppression of T-cell function by exogenous ADO and CD4 and plus; CD73 and plus; T cells."Authors Schuler PJ,Macatangay BJ,Saze Z,Jackson EK,Riddler SA,Buchanan WG,Hilldorfer BB,Mellors JW,Whiteside TL,Rinaldo CR4.Epigenetics and chromatinGeneration of bivalent chromatin domains during cell fate decisions."11-0389 was used in Flow cytometry/Cell sorting to investigate the patterns and levels of histone modifications at bivalent genes, showing the generation of bivalent chromatin domains during cell fate decisions."Authors De Gobbi M,Garrick D,Lynch M,Vernimmen D,Hughes JR,Goardon N,Luc S,Lower KM,Sloane-Stanley JA,Pina C,Soneji S,Renella R,Enver T,Taylor S,Jacobsen SE,Vyas P,Gibbons RJ,Higgs DR5.The Biochemical journalCD38 binding to human myeloid cells is mediated by mouse and human CD31.Authors Horenstein AL,Stockinger H,Imhof BA,Malavasi F

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