CD11c Monoclonal Antibody (N418), FITC, eBioscience™

货号：11-0114-81,11-0114-82,11-0114-85

规格：50 µg,100 µg,500 µg

价格：953,1698,3183

产品类型：流式抗体

品牌：eBioscience

抗原：CD11c

物种：人/小鼠

宿主：Armenian hamster仓鼠

抗体亚型：IgG

克隆号：N418

荧光染料：FITC

抗体类型:	流式抗体	同型对照：	Armenian Hamster IgG Isotype Control (eBio299Arm), FITC, eBioscience™
浓度：	0.5 mg/mL	用法：	0.25 µg/test (Flow）

产品详细信息Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alphaX. CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.Applications Reported: The N418 antibody has been reported for use in flow cytometric analysis.Applications Tested: The N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.25 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered. 靶标信息CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes.

数据

CD11c Antibody (11-0114-82) in FlowStaining of C57BL/6 splenocytes with Anti-Human/Mouse CD45R (B220) APC(Product # 17-0452-82) and 0.125 µg of Armenian Hamster IgG Isotype Control FITC (Product # 11-4888-81) (left) or 0.125 µg of Anti-Mouse CD11c FITC (right). Total viable cells were used for analysi CD11c Antibody (11-0114-81) Journal of visualized experiments : JoVE 2017 -Published figure using CD11c monoclonal antibody (Product # 11-0114-81)

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参考文献：

1.Frontiers in immunology FcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells.2.Journal of Cancer PD-1 Blockade Overcomes Adaptive Immune Resistance in Treatment with Anchored-GM-CSF Bladder Cancer Cells Vaccine.3.Oncoimmunology LYG1 exerts antitumor function through promoting the activation, proliferation, and function of CD4+ T cells.4.Frontiers in immunology MicroRNA-155 Protects Group 2 Innate Lymphoid Cells From Apoptosis to Promote Type-2 Immunity.5.Journal of cellular and molecular medicine Cytochrome P450 26A1 modulates uterine dendritic cells in mice early pregnancy.

技术参数

产品应用 Flow；IF；ICC；IHC；IHC (F)

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