CD31 (PECAM-1) Monoclonal Antibody (WM-59 (WM59)), APC

货号：17-0319-41,17-0319-42

规格：25 Tests,100 Tests

价格：1132,2431

产品类型：流式抗体

品牌：Thermo Fisher

物种：人/小鼠/非人灵长类/猪/恒河猴

宿主：小鼠

抗体亚型：IgG1, kappa

克隆号：WM-59 (WM59)

荧光染料：APC

抗体类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control, APC, eBioscience™
免疫原性：		用法：	5uL（0.5µg）/test(Flow）

Description: The WM59 monoclonal antibody reacts with human CD31, also known as platelet-endothelial cell adhesion molecule-1 (PECAM-1) and gpIIa. This 130-140 kDa surface protein is expressed by endothelial cells and at low levels on leukocytes and platelets. It has been reported that CD38 binds to CD31. Homotypic interaction of CD31 is important in adhesion, cell-cell and cell-matrix interaction, and signal transduction.Applications Reported: The WM-59 (WM59) antibody has been reported for use in flow cytometric analysis.Applications Tested: This WM-59 (WM59) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.5 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationCD31 (platelet endothelial cell adhesion molecule-1, PECAM-1) is an inhibitory coreceptor involved in regulation of T cell and B cell signaling by a dual immunoreceptor tyrosine-based inhibitory motif (ITIM) that upon associated kinases-mediated phosphorylation provide docking sites for protein-tyrosine phosphatases. CD31 is expressed ubiquitously within the vascular compartment and is located mainly at junctions between adjacent cells. N-terminal Ig-like domain of CD31 is responsible for its homophilic binding, which plays an important role in cell-cell interactions. CD31 is a multifunctional molecule with diverse roles in modulation of integrin-mediated cell adhesion, transendothelial migration, angiogenesis, apoptosis, negative regulation of immunoreceptor signaling, autoimmunity, macrophage phagocytosis, IgE-mediated anaphylaxis and thrombosis. It is one of key regulatory molecules in vascular system.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

CD31 (PECAM-1) Antibody (17-0319-42) in Flow Staining of normal human peripheral blood cells with Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (blue histogram) or Anti-Human CD31 (PECAM-1) APC (purple histogram). Cells in the monocyte gate were used for analysis

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参考文献：

1. Stem cell reportsTargeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer2. Stem cell research and therapyERK signaling is required for VEGF-A/VEGFR2-induced differentiation of porcine adipose-derived mesenchymal stem cells into endothelial cells....By clicking the link above, you will be redirected to the Benchsci website.Disclaimer3. eLifeTGF-β reduces DNA ds-break repair mechanisms to heighten genetic diversity and adaptability of CD44+/CD24- cancer cells.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer4. Stem cell reportsInVitro Modeling of Blood-Brain Barrier with Human iPSC-Derived Endothelial Cells, Pericytes, Neurons, and Astrocytes via Notch Signaling."17031942 was used in flow cytometry to differentiate human induced pluripotent stem cells into all four cell populations within the blood brain barrier"AuthorsYamamizu K,Iwasaki M,Takakubo H,Sakamoto T,Ikuno T,Miyoshi M,Kondo T,Nakao Y,Nakagawa M,Inoue H,Yamashita JK5. Stem cells translational medicineMMP-2 and MMP-14 Silencing Inhibits VEGFR2 Cleavage and Induces the Differentiation of Porcine Adipose-Derived Mesenchymal Stem Cells to Endothelial Cells."17-0319 was used in Flow cytometry/Cell sorting to reveal a regulatory role of matrix metalloproteinase expression for mesenchymal stem cell differentiation."AuthorsAlmalki SG,Llamas Valle Y,Agrawal DK

技术参数

产品应用 Flow

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