CD206 (MMR) Monoclonal Antibody (19.2), APC

货号：17-2069-41,17-2069-42

规格：25 Tests,100 Tests

价格：1132,2947

产品类型：流式抗体

品牌：Thermo Fisher

物种：人

宿主：小鼠

抗体亚型：IgG

荧光染料：APC

抗体类型:	单抗	同型对照：	Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), APC, eBioscience™
免疫原性：		用法：	5uL（0.06µg）/test(Flow）

Description: This 19.2 monoclonal antibody reacts with human CD206, which is also known as the macrophage mannose receptor (MMR). CD206 is expressed on macrophages and dendritic cells. This type I transmembrane protein can also be detected on non-immune cells, including hepatic and lymphathic epithelia and kidney mesengial cells. CD206 binds to glycoproteins that terminate in D-mannose, L-fucose, or N-acetylglucosamine, as well as a variety of hormones. This receptor undergoes constitutive internalization and recycling between the plasma membrane and the endosomal compartment. CD206 is involved in antigen processing and presentation, cell migration, and intracellular signaling. Moreover, CD206 plays a key role in phagocytosis pathogens such as Candida albicans, Leishmania, and Mycobacterium tuberculosis.Applications Reported: This 19.2 antibody has been reported for use in flow cytometric analysis.Applications Tested: This 19.2 antibody has been pre-titrated and tested by flow cytometric analysis of stimulated normal human peripheral blood monocytes. This can be used at 5 µL (0.06 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 633-647 nm; Emission: 660 nm; Laser: Red Laser.Filtration: 0.2 µm post-manufacturing filtered.Background/Target InformationMannose receptor, also know as CD206, is a 175kDa transmembrane protein belonging to the group of pattern recognition receptors. CD206 is predominantly expressed in tissue macrophages and dentritic cells and can also be found in a subpopulation of endothelial cells and sperm cells. CD206 is thought to play a role in the innate and adaptive immune response.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

CD206 (MMR) Antibody (17-2069-42) in FlowNormal human peripheral blood cells were cultured for 3 days with Human GM-CSF Recombinant Protein (Product # 14-8339-62). Cells were stained with Mouse IgG1 K Isotype Control APC (Product # 17-4714-81) (blue histogram) or Anti-Human CD206 (MMR) APC (purple histogram). Total viable monocytes/macrophages, as determined by Fixable Viability Dye eFluor® 450, were used for analysis.

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参考文献：

1. Frontiers in pharmacologyGinsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype."17-2069 was used in Flow cytometry/Cell sorting to demonstrate an immunomodulatory role of ginsenoside 20(S)-Rg3 in promoting macrophages to a profile of the M2 type through PPARγ-dependent mechanisms."AuthorsGuo M,Xiao J,Sheng X,Zhang X,Tie Y,Wang L,Zhao L,Ji X2. Molecular metabolismMetabolic reprogramming through fatty acid transport protein 1 (FATP1) regulates macrophage inflammatory potential and adipose inflammation."17-2069 was used in Flow cytometry/Cell sorting to outline a novel mechanism for regulating adipose tissue homoeostasis and inflammation through metabolic reprogramming of macrophages; directed by fatty acid transport protein 1."AuthorsJohnson AR,Qin Y,Cozzo AJ,Freemerman AJ,Huang MJ,Zhao L,Sampey BP,Milner JJ,Beck MA,Damania B,Rashid N,Galanko JA,Lee DP,Edin ML,Zeldin DC,Fueger PT,Dietz B,Stahl A,Wu Y,Mohlke KL,Makowski L3. Journal of immunology (Baltimore, Md. : 1950)γ-Tilmanocept, a New Radiopharmaceutical Tracer for Cancer Sentinel Lymph Nodes, Binds to the Mannose Receptor (CD206)."17-2069 was used in Flow cytometry/Cell sorting to provide strong evidence that CD206 is a major binding receptor for γ-tilmanocept."AuthorsAzad AK,Rajaram MV,Metz WL,Cope FO,Blue MS,Vera DR,Schlesinger LS4. The Journal of biological chemistryDoxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization. By clicking the link above, you will be redirected to the Benchsci website.Disclaimer5. Nature communicationsmiR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.By clicking the link above, you will be redirected to the Benchsci website.Disclaimer

技术参数

产品应用 Flow

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