Lamin B2 Monoclonal Antibody (E-3), Alexa Fluor 647
货号：MA3-32100- A647
规格：50 µl
价格：4223
产品类型：流式抗体
品牌：Thermo Fisher
物种：人/小鼠/大鼠
宿主：兔
抗体亚型：其它
荧光染料：Alexa Fluor 647
类型: | 多抗 | 同型对照： | IgG1, kappa |
免疫原性： | Extracts from chicken nuclei | 用法： | 1-10 µg/mL(IF) |
Target InformationNuclear lamins form a network of intermediate-type filaments at the nucleoplasmic site of the nuclear membrane. Two main subtypes of nuclear lamins can be distinguished, i.e. A-type lamins and B-type lamins. The A-type lamins comprise a set of three proteins arising from the same gene by alternative splicing, i.e. lamin A, lamin C and lamin Adel 10, while the B-type lamins include two proteins arising from two distinct genes, i.e. lamin B1 and lamin B2. Recent evidence has revealed that mutations in A-type lamins give rise to a range of rare but dominant genetic disorders, including Emery-Dreifuss muscular dystrophy, dilated cardiomyopathy with conduction-system disease and Dunnigan-type familial partial lipodystrophy. In addition, the expression of A-type lamins coincides with cell differentiation and as A-type lamins specifically interact with chromatin, a role in the regulation of differential gene expression has been suggested for A-type lamins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
数据 |
Lamin B2 Antibody (MA3-32100-A647) in IFImmunofluorescent analysis of Lamin B2 (red) in HeLa cells. The cells were fixed with 4% Paraformaldehyde in PBS for 15 minutes at room temperature, and blocked with 3% BSA in PBS (Product # 37525) for 30 minutes at room temperature. Cells were stained with a Lamin B2 Monoclonal Antibody, AlexaFluor 647 conjugate (Product # MA3-32100-A647) at a dilution of 1.25 µg/mL in blocking buffer for 1 hour at room temperature protected from light. Nuclei (blue) were stained with Hoechst Dye (Product # 62249) at a dilution of 1:10,000 in blocking buffer. Images were taken on a Thermo Scientific ToxInsight Instrument at 20X magnification. |
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