c-Myc Monoclonal Antibody (289-19510)

货号：A21280

规格：100 µL

价格：0

产品类型：流式抗体

品牌：Thermo Fisher

抗原：c-Myc

物种：人/小鼠

宿主：小鼠

抗体亚型：其它

克隆号：289-19510

荧光染料：其它

类型:	单抗	同型对照：	IgG1
免疫原性：	Raised against the peptide AEEQKLISEEDLLRKRREQLKHKLEQLRNSCA that corresponds to amino acids 408–439 of the human c-myc protein.	用法：	1-10 µg/mL(IHC)

Target InformationThe c-Myc protein is a 62 kDa transcription factor that is encoded by the c-Myc gene on human chromosome 8q24. c-Myc is commonly activated in a variety of tumor cells and plays an important role in cellular proliferation, differentiation, apoptosis and cell cycle progression. The phosphorylation of c-Myc has been investigated and previous studies have suggested a functional association between phosphorylation at Thr58/Ser62 by glycogen synthase kinase 3, cyclin dependent kinase, ERK2 and C-Jun N terminal Kinase (JNK) in cell proliferation and cell cycle regulation. Studies have shown that c-Myc is essential for vasculogenesis and angiogenesis in tumor development, which distributes blood throughout the cells. The c-myc oncogene (p62 c-myc) is involved in the control of normal cellular proliferation and differentiation, and the deregulated expression of c-Myc induces apoptosis in different cell types. Antibodies against c-myc epitopes recognize overexpressed proteins containing Myc epitope tag fused to either amino- or carboxy-termini of targeted proteins. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas, while the N-Myc gene has been found amplified in neuroblastomas. Translocation of the c-myc locus on chromosome 8 to the immunoglobulin loci on chromosome 14 (heavy chain); 2 (delta light chain); or 22 (light chain) is described in Burkitts lymphoma and other B-cell lymphoproliferative conditions. An aberrant expression of the c-myc gene occurs in tumors of different origins such as colorectal, gastric, gallbladder, hepatic, mammary, ovarian, endometrial, head and neck, pulmonary, prostatic, thyroidal, oral, ocular, nasopharyngeal, endocrine, as well as hematopoietic neoplasms.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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参考文献：

1.Clinical breast cancerMYC Amplification as a Predictive Factor of Complete Pathologic Response to Docetaxel-based Neoadjuvant Chemotherapy for Breast Cancer."A-21280 was used in immunohistochemistry to identify biomarkers to use for patients receiving neoadjuvant chemotherapy to treat breast cancer"AuthorsPereira CBL,Leal MF,Abdelhay ESFW,Demachki S,Assumpção PP,de Souza MC,Moreira-Nunes CA,Tanaka AMDS,Smith MC,Burbano RR2.EMBO reportsA non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis through PCM1 phosphorylation."A-21280 was used in immunocytochemistry to assess PCM1 phosphorylation as a non-canonical function of Plk4 in centriolar satellite integrity and ciliogenesis"AuthorsHori A,Barnouin K,Snijders AP,Toda T3.The Journal of biological chemistryDesign and Optimization of Anti-amyloid Domain Antibodies Specific for β-Amyloid and Islet Amyloid Polypeptide.4.The Journal of biological chemistryFunctional protein delivery into neurons using polymeric nanoparticles."A-21280 was used in immunocytochemistry and western blot to use polybutylcyanoacrylate nanoparticles to introduce functional proteins into neurons and neuronal cell lines"AuthorsHasadsri L,Kreuter J,Hattori H,Iwasaki T,George JM5.PloS oneNovel MeCP2 isoform-specific antibody reveals the endogenous MeCP2E1 expression in murine brain, primary neurons and astrocytes.View published figure on

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