OCT4 Polyclonal Antibody

货号：PA5-86191

规格：100 µL

价格：4732

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人/小鼠/大鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

类型:	多抗	同型对照：	IgG
免疫原性：	Synthetic peptide, corresponding to the N-terminus of Human Oct-2.	用法：	1:50-1:200(ICP);1:500-1:1000(WB)

Target InformationOct4 is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. Oct4 is one of the four Yamaka factors, necessary for embryonic stem cell pluripotency. Pluripotent stem (iPS) cells, can be created by expressing Oct4 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Oct4, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. A translocation of this gene with the Ewing's sarcoma gene, t(6;22)(p21;q12), has been linked to tumor formation.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

OCT4 Antibody (PA5-86191) in WBWestern blot analysis of OCT4 in Lane 1: HEK293T whole cell lysate (40 µg), Lane 2: L02 whole cell lysate (40 µg), Lane 3: brain tissue lysate of mouse (40 µg), Lane 4: brain tissue lysate of rat (40 µg). Sample was incubated with OCT4 polyclonal antibody (Product # PA5-86191) using a 1:500 dilution. OCT4 Antibody (PA5-86191) in IHC (P)Immunohistochemical analysis of OCT4 in paraffin-embedded human breast carcinoma tissue. Sample was incubated with polyclonal OCT4 antibody (Product # PA5-86191) using a 1:100 dilution.

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