OCT4 Polyclonal Antibody
货号：PA5-20887
规格：100 ug
价格：4880
产品类型：免疫组化一抗
品牌：Thermo Fisher
物种：人/小鼠/大鼠
宿主：兔
抗体亚型：IgG
荧光染料：Purified
类型: | 多抗 | 同型对照： | IgG |
免疫原性： | A 14 amino acid peptide near the carboxy terminus of human POU5F1. | 用法： | 5.0 µg/mL(IHC);1 µg/mL(WB) |
Product Specific InformationA suggested positive control is mouse liver tissue lysate.PA5-20887 can be used with blocking peptide PEP-1001.Target InformationPOU5F1, also commonly known as Oct-4, is a maternally expressed octamer-binding protein that was the first transcription factor described for the early stages of development. The role of POU5F1 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing POU5F1 and the transcription factors Sox2, Klf4 and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing POU5F1, Sox2, KlfF4 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
数据 |
| OCT4 Antibody (PA5-20887) in IHCImmunohistochemical staining of rat liver tissue using a POU5F1 polyclonal antibody (Product # PA5-20887) at a 5 µg/mL dilution. |
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