LIN28A Polyclonal Antibody

货号：PA5-20898

规格：100 ug

价格：4880

产品类型：免疫组化一抗

品牌：Thermo Fisher

物种：人

宿主：兔

抗体亚型：IgG

荧光染料：Purified

类型:	多抗	同型对照：	IgG
免疫原性：	A 15 amino acid peptide near the carboxy terminus of human Lin28.	用法：	20µg/mL(ICC);20 µg/mL(IF);1 -2µg/mL(WB);5 µg/mL(IHC)

Product Specific InformationA suggested positive control is Raji cell lysate.PA5-20898 can be used with blocking peptide PEP-1012.Target InformationLin28 is a transcription factor that was first identified through its key role in the pathway of developmental timing in C. elegans. The role of Lin28 in development suggested that it might be useful in the creation of stem cells that might be beneficial in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing Lin28 in addition to the transcription factors POU5F1, Sox2, and NANOG in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing Lin28, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine.For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

数据

LIN28A Antibody (PA5-20898) in IFImmunofluorescent analysis of human spleen tissue using a Lin28 polyclonal antibody (Product # PA5-20898) at a 20 µg/mL dilution. LIN28A Antibody (PA5-20898) in WBWestern blot analysis of Raji cell lysate using a Lin28 polyclonal antibody (Product # PA5-20898) at (A) 1 and (B) 2 µg/mL. LIN28A Antibody (PA5-20898) in IHCImmunohistochemical staining of human spleen tissue using a Lin28 polyclonal antibody (Product # PA5-20898) at a 5 µg/mL dilution.

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