SOX1 Polyclonal Antibody

货号：PA5-23370

规格：100 µg

价格：4880

产品类型：免疫组化一抗

品牌：eBioscience

物种：人/小鼠

宿主：兔

抗体亚型：IgG

荧光染料：Purified

类型:	多抗	同型对照：
浓度：	0.5 mg/mL	用法：	0.5-3 µg/mL(WB)
免疫原性：	Synthetic peptide (366 SRLHSLPQHYQGAGA 380) of SOX1 protein

靶标信息SOX1, also known as SRY (sex determining region Y)-box 1, is a transcription factor belonging to the SRY-related HMG box family of transcription factors with a HMG box DNA-binding domain. SOX1 works through multiple independent pathways to promote neuronal cell fate determination and differentiation. This nuclear protein acts as a modulator of LINE retroposons promoter activity and is also involved in the development of the central nervous system, mainly neural and lens development. Transcriptional activator SOX1 binds directly to the HES1 promoter and suppresses HES1 transcription, thus attenuating Notch signaling. It also binds to beta-catenin and suppresses beta-catenin-mediated TCF/LEF signaling, thus potentially attenuating the WNT signaling pathway. Expression of SOX1 is seen mostly in embryonic tissues and moderately in brain.

数据

SOX1 Antibody (PA5-23370) in WBWestern blot analysis of SOX1 in human brain lysate in the 1) absence and 2) presence of immunizing peptide and 3) mouse brain lysate using a SOX1 polyclonal antibody (Product # PA5-23370) at 0.5 µg/mL, 0.5 µg/mL and2 µg/mL respectively. Goat anti-rabbit Ig HRP secondary antibody.

二抗荧光二抗免疫组化一抗标签抗体

参考文献：

技术参数

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