CD9 Monoclonal Antibody (MEM-61), Biotin/CD9单抗 (MEM-61), Biotin

货号： MA1-19485

规格：100 µg

价格：4880

产品类型：免疫组化一抗

品牌：Thermo Fisher

抗原：Pre-B cell line NALM-6.

物种：人

宿主：小鼠

抗体亚型：其它

克隆号：MEM-61

荧光染料：其它

类型:	单抗	同型对照：	IgG1
浓度：	1 mg/mL	用法：	1:400(Flow);(IHC(P));(WB)

产品详细信息This antibody recognizes an epitope on second extracellular domain (EC2) of CD9 antigen.靶标信息CD9 antigen is a glycoprotein expressed on the surface of developing B lymphocytes, platelets, monocytes, eosinophils, basophil, stimulated T lymphocytes and by neurons and glial cells in the peripheral nervous system. CD9 belongs to a family of membrane proteins termed tetraspanins which transverse the membrane four times. In pre B cells and platelets, CD9 antigen regulates cell activation and aggregation possibly through an association with the integrin CD41 / CD61 (GPIIb / GPIIIa). CD9 is involved in cell motility, osteoclastogenesis, neurite outgrowth, myotube formation, and sperm-egg fusion, plays roles in cell attachment and proliferation and is necessary for association of heterologous MHC II molecules on the dendritic cell plasma membrane which is important for effective T cell stimulation. CD9 functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression plays a critical role in the suppression of cancer cell motility and metastasis. CD9 is also considered as metastasis suppressor in solid tumors.

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