Anti-Human CD28 SAFIRE Purified/抗人CD28 SAFIRE Purified

货号：10311-25-100,10311-25-500

规格：100 μg,500 μg

价格：1820,3640

产品类型：流式抗体

品牌：Biogems

物种：人

宿主：小鼠

抗体亚型：其它

克隆号： CD28.2

荧光染料：其它

类型:	单抗	同型对照：	Mouse IgG1, kappa
浓度：		用法：

The CD28.2 monoclonal antibody specifically binds with the human 44 kDa homodimeric trans-membrane glycoprotein CD28, expressed on the surface of most mature T lymphocytes, plasma cells, and thymocytes. CD28 is a ligand for B7-1 (CD80) and B7-2 (CD86), a co-stimulator of T lymphocytes, and enhances the interaction between T and B lymphocytes. It has been reported that the T lymphocytes stimulation to produce IL-2 depends on the monoclonal antibody involved, which suggests that the CD28 molecule presents some subregions with distinct functions. The CD28.2 antibody induces Ca2+ influx in Jurkat T lymphocytes. Other studies have shown that CD28 is involved in the signal transduction.

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参考文献：

1.Schlossman, S., L. Bloumsell, et al. eds (1995). Leucocyte Typing V: White Cell Differentiation Antigens. Oxford University Press. New York2.Nunès, J., Klasen, S., Ragueneau, M., Pavon, C., Couez, D., Mawas, C., ... & Olive, D. (1993). CD28 mAbs with distinct binding properties differ in their ability to induce T cell activation: analysis of early and late activation events.International immunology,5(3), 311-315.3.Karlsson, I., Malleret, B., Brochard, P., Delache, B., Calvo, J., Le Grand, R., & Vaslin, B. (2007). FoxP3+ CD25+ CD8+ T-cell induction during primary simian immunodeficiency virus infection in cynomolgus macaques correlates with low CD4+ T-cell activation and high viral load.Journal of virology,81(24), 13444-13455.

技术参数

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