CD5 Monoclonal Antibody (UCHT2), FITC, eBioscience™
货号：11-0059-42
规格：100 tests
价格：1855
产品类型：流式抗体
品牌：eBioscience
抗原：CD5
物种：人
宿主：小鼠
抗体亚型：IgG
克隆号：UCHT2
荧光染料：FITC
| 抗体类型: | 流式抗体 | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience™ |
| 浓度： | 5 µL/Test | 用法： | 5uL（1µg）/test (Flow） |
| 产品详细信息Description: The UCHT2 monoclonal antibody reacts with human CD5, a 67 kDa protein expressed by a majority of thymocytes and mature T cells and a subset of B cells. Signaling through the CD5 molecule activates T cells and binding of CD5 to its ligand on B cells, CD72, and plays an important role in T-B interaction and proliferation.The monoclonal antibody UCHT2 recognizes primate CD5.Applications Reported: The UCHT2 antibody has been reported for use in flow cytometric analysis.Applications Tested: This UCHT2 antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (1 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered. 靶标信息CD5 is a 67 kDa human T-lymphocyte single-chain transmembrane glycoprotein. CD5 is present on all mature T-lymphocytes, on most of thymocytes and on many T-cell leukemias and lymphomas. CD5 also reacts with a subpopulation of activated B-cells and may act as a receptor in regulating T-cell proliferation. CD5 is found on 95% of thymocytes and 72% of peripheral blood lymphocytes. In lymph nodes, the main reactivity is observed in T cell areas. CD5 is expressed by many T cell leukemia, lymphomas, and activated T cells. Diseases associated with CD5 dysfunction include thymus cancer and Richter's Syndrome. |
| 数据 |
CD5 Antibody (11-0059-41) in Flow Staining of normal human peripheral blood cells with Mouse IgG1 kappa Isotype Control FITC (Product # 11-4714-42) (open histogram) or Anti-Human CD5 FITC (filled histogram). Cells in the lymphocyte gate were used for analysis.CD5 Antibody (11-0059-41)Stem cell reports 2017 - Figure 7 HEBCan Rescues Hematopoiesis and T Cell Development in HEB -/- hESCs in OP9-DL4 Co-cultures (A) qRT-PCR analysis for the expression of hematopoietic genes in CD34 + cells sorted from WT, KO + GFP, and KO + HEBCan day-8 (d8) EBs. mRNA levels are shown relative to GAPDH. (B and C) Percentages (B) and numbers (C) of CD45 + cells in d12 and d18 OP9-DL4 co-cultures. (D and E) Flow-cytometric analysis of T cell development from WT, KO + GFP, and KO + HEBCan d8 EB-derived CD34 + cells at d12 (D) and d18 (E) of OP9-DL4 co-culture. Cells are gated on the CD45 + DAPI - population. Error bars represent mean +- SD (n = 3 independent experiments). * p < 0.05, ** p < 0.01, *** p < 0.005 by Student's t test. Plots in (B), (D), and (E) are representative of three independent experiments. |
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| 参考文献： |
| 1.Stem cell reports Targeted Disruption of TCF12 Reveals HEB as Essential in Human Mesodermal Specification and Hematopoiesis.2.Cell Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.3.Clinical cancer research : an official journal of the American Association for Cancer Research A pathobiological role of the insulin receptor in chronic lymphocytic leukemia.4.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. |
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