CD8a Monoclonal Antibody (SK1), FITC, eBioscience™
货号：11-0087-41,11-0087-42
规格：25 tests,100 tests
价格：1244,2387
产品类型：流式抗体
品牌：eBioscience
抗原：CD8a
物种：人
宿主：小鼠
抗体亚型：IgG1, kappa
克隆号：SK1
荧光染料：FITC
| 抗体类型: | 流式抗体 | 同型对照： | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), FITC, eBioscience |
| 浓度： | 5 µL/Test | 用法： | 5 µL (0.125 µg)/test (Flow） |
产品详细信息Description: The SK1 monoclonal antibody reacts with the human CD8a molecule, an approximately 32-34 kDa cell surface receptor expressed either as a heterodimer with the CD8 beta chain (CD8 alpha/beta) or as a homodimer (CD8 alpha/alpha). A majority of thymocytes and a subpopulation of mature T cells and NK cells express CD8a. CD8 binds to MHC class I and through its association with protein tyrosine kinase p56lck plays a role in T-cell development and activation of mature T cells.Applications Reported: This SK1 (SK-1) antibody has been reported for use in flow cytometric analysis.Applications Tested: This SK1 (SK-1) antibody has been pre-titrated and tested by flow cytometric analysis of normal human peripheral blood cells. This can be used at 5 µL (0.125 µg) per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test.Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser.Filtration: 0.2 µm post-manufacturing filtered. 靶标信息CD8 molecule is composed of two chains termed alpha and beta. CD8 is found on a T cell subset of normal cytotoxic / suppressor cells which make up approximately 20 to 35% of human peripheral blood lymphocytes. The CD8 antigen is also detected on natural killer cells, 80% of thymocytes, on a subpopulation of 30% of peripheral blood null cells and 15 to 30% of bone marrow cells.
| 数据 |
| CD8a Antibody (11-0087-41) in Flow Staining of normal human peripheral blood cells with Anti-Human CD3 APC (Product # 17-0037-42) and Mouse IgG1 K Isotype Control FITC (Product # 11-4714-42) (left) or Anti-Human CD8a FITC (right). Cells in the lymphocyte gate were used for analysis. |
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| 参考文献： |
| 1.Cancer immunology researchProgression of Lung Cancer Is Associated with Increased Dysfunction of T Cells Defined by Coexpression of Multiple Inhibitory Receptors."11-0087 was used in Flow cytometry/Cell sorting to characterise the diversity and expression patterns of inhibitory receptors on tumour-infiltrating T cells from patients with non-small cell lung cancer." |
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