| 产品详细信息Description: The N418 monoclonal antibody reacts with mouse CD11c, the integrin alphaX. CD11c non-covalently associates with beta2 integrin to form the CD11c/CD18 heterodimer. CD11c is expressed by dendritic cells, a subset of Intestinal Intraepithelial Lymphocytes (IEL) and some activated T cells. CD11c/CD18 binds to CD54, iC3b and fibrinogen and plays a role in leukocyte adhesive interactions. N418 binds to CD11c on splenic dendritic cells in the T-dependent areas of mouse spleen and precipitates a 150, 90 kDa heterodimer.Applications Reported: The N418 antibody has been reported for use in flow cytometric analysis.Applications Tested: The N418 antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 0.5 µg per test. A test is defined as the amount (µg) of antibody that will stain a cell sample in a final volume of 100 µL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.Excitation: 488-561 nm; Emission: 578 nm; Laser: Blue Laser, Green Laser, Yellow-Green Laser.Filtration: 0.2 µm post-manufacturing filtered.靶标信息CD11, along with CD18, form a heterodimer adhesion molecule. In particular, CD11 is composed of CD11a, CD11b and CD11c. CD11a is a leukocyte marker that is expressed in B and T lymphocytes, macrophages, monocytes, neutrophils, basophils and eosinophils. CD11b is primarily expressed by monocytes, macrophages, natural killer cells, some B and T-cells, and granulocytes. CD11c is expressed in monocytes, macrophages, natural killer cells, some granulocytes and less so in a subset of lymphocytes. |
| 1.Frontiers in immunologyFcεRI γ-Chain Negatively Modulates Dectin-1 Responses in Dendritic Cells."Published figure using CD11c monoclonal antibody (Product # 12-0114-82) in Flow Cytometry"2.Frontiers in immunologyMicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4."12-0114 was used in Flow cytometry/Cell sorting to study the role of microRNA-7 in acute lung injury, allowing the development of new therapeutic strategies against inflammatory lung disease."AuthorsZhao J,Chen C,Guo M,Tao Y,Cui P,Zhou Y,Qin N,Zheng J,Zhang J,Xu L3.Frontiers in microbiologyEbola Virus Glycoprotein Induces an Innate Immune ResponseIn vivovia TLR4."12-0114 was used in Flow cytometry/Cell sorting to investigate the early immune response to purified Ebola virus glycoprotein alone in vitro and in vivo."AuthorsLai CY,Strange DP,Wong TAS,Lehrer AT,Verma S4.Nature communicationsEfficient oral vaccination by bioengineering virus-like particles with protozoan surface proteins."12-0114 was used in Flow cytometry/Cell sorting to study the use of bioengineered virus-like particles with protozoan surface proteins in oral vaccination."AuthorsSerradell MC,Rupil LL,Martino RA,Prucca CG,Carranza PG,Saura A,Fernández EA,Gargantini PR,Tenaglia AH,Petiti JP,Tonelli RR,Reinoso-Vizcaino N,Echenique J,Berod L,Piaggio E,Bellier B,Sparwasser T,Klatzmann D,Luján HD5.Frontiers in immunologyMicroRNA-7 Deficiency Ameliorates the Pathologies of Acute Lung Injury through Elevating KLF4."12-0114 was used in Flow cytometry/Cell sorting to study the role of microRNA-7 in acute lung injury, allowing the development of new therapeutic strategies against inflammatory lung disease."AuthorsZhao J,Chen C,Guo M,Tao Y,Cui P,Zhou Y,Qin N,Zheng J,Zhang J,Xu L |
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