Human ErbB4 ELISA Kit/人ErbB4 ELISA试剂盒
货号：EH175RB,EH175RBX5,EH175RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.2 ng/mL |
| 检测范围 | 0.2-50 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | ErbB4 |
| Protein aliases | 4ICD, avian erythroblastic leukemia viral (v-erb-b2) oncogene homolog 4, ERBB4 intracellular domain, ERBB4 transcript variant I12DEL, ERBB4 transcript variant I20DEL, human epidermal growth factor receptor 4, p180erbB4, Proto-oncogene-like protein c-ErbB-4, Receptor tyrosine-protein kinase erbB-4, s80HER4, Tyrosine kinase-type cell surface receptor HER4, v-erb-a erythroblastic leukemia viral oncogene homolog 4, v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | ALS19, ERBB4, HER4, p180erbB4 |
| Gene ID | (Human) 2066 |
| Gene symbol | ERBB4 |
| UniProt ID | (Human) Q15303 |
| Human ErbB4 quantitates human ErbB4 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human ErbB4.人ErbB4定量检测血清，血浆，上清液中的人ErbB4。 该检测试剂盒将只识别天然和重组人ErbB4。Target information 靶标信息ErbB 4 (Her-4, c-erbB-4, v-erbB-4) is a member of the class I receptor kinase family. With more than 500 gene products, the protein kinase family is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/threonine (STK) kinase catalytic domains. ErbB 4 is activated by neuregulins and NTAK (neural and thymus derived activator for ErbB kinases). ErbB 4 is a receptor for heregulin and is capable of mediating HGL-stimulated tyrosine phosphorylation of itself. Like other protein kinases, ErbB 4 mediate most of the signal transduction in eukaryotic cells, regulating cellular metabolism, transcription, cell cycle progression, cytoskeletal rearrangement and cell movement, apoptosis, and differentiation. ErbB 4 is most predominantly expressed in several breast carcinoma cell lines, and in normal skeletal muscle, heart, pituitary, brain, and cerebellum. Breast tumor cell lines T47-D, MDA-MB-453, BT-474 and H3396 are found to have the highest levels of mRNA, and intermediate levels are seen in MCF-7, MDAMB-330 and MDA-MB-361. Expression of ErbB 4 is low or absent in some breast tumor cell lines such as MDA-MB-231, MDA-MB-157, MDA-MB-468, and SKBR-3. ErbB 4 levels have been found to be elevated in certain human tumor cell lines suggesting that it may play a role in some malignancies.ErbB 4（Her-4，c-erbB-4，v-erbB-4）是I类受体激酶家族的成员。蛋白激酶家族拥有500多种基因产物，是真核生物中最大的蛋白家族之一。根据其酪氨酸（PTK）或丝氨酸/苏氨酸（STK）激酶催化域的序列比较，该家族已分为8大类。 ErbB 4被神经调节蛋白和NTAK（神经和胸腺的ErbB激酶激活剂）激活。 ErbB 4是调蛋白的受体，能够介导HGL刺激的酪氨酸磷酸化。与其他蛋白激酶一样，ErbB 4介导真核细胞中的大多数信号转导，调节细胞代谢，转录，细胞周期进程，细胞骨架重排和细胞运动，细胞凋亡和分化。 ErbB 4最主要在几种乳腺癌细胞系中以及正常骨骼肌，心脏，垂体，大脑和小脑中表达。发现乳腺癌细胞系T47-D，MDA-MB-453，BT-474和H3396的mRNA水平最高，在MCF-7，MDAMB-330和MDA-MB-361中处于中等水平。在某些乳腺肿瘤细胞系（例如MDA-MB-231，MDA-MB-157，MDA-MB-468和SKBR-3）中，ErbB 4的表达较低或不存在。已经发现在某些人肿瘤细胞系中ErbB 4水平升高，表明它可能在某些恶性肿瘤中起作用。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。不用于诊断过程。未经明确授权不得转售。 |
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