MLL1 Recombinant Rabbit Monoclonal Antibody (BL-175-7E8)
货号：A700-010
规格：100μL
价格：4158
产品类型：标签抗体
品牌：Thermo Fisher
抗原：Between 720 and 780
物种：人
宿主：兔
抗体亚型：IgG
克隆号：BL-175-7E8
荧光染料：其它
| 类型: | 一抗 | 同型对照： | |
| 浓度： | 1 mg/mL | 用法： | 10 µl/0.5 mg lysate (IP);1:1,000(WB) |
产品详细信息The recommended shelf life for this product is 1 year from date of receipt. 靶标信息KMT2A is a histone methyltransferase that plays an essential role in early development and hematopoiesis. It is a catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac). In the MLL1/MLL complex, KMT2A specifically mediates H3K4me, a tag for epigenetic transcriptional activation. KMT2A has weak methyltransferase activity by itself, and requires other components of the MLL1/MLL complex to obtain full methyltransferase activity. It has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', and has higher activity toward H3 acetylated on 'Lys-9'. Required for transcriptional activation of HOXA9 and promotes PPP1R15A-induced apoptosis.
| 数据： |
| MLL1 Antibody (A700-010) in WB Detection of human MLL1 by WB of immunoprecipitates from 293T lysate. Antibodies: Rabbit anti-MLL1 recombinant monoclonal [BL-175-7E8] (A700-010) and rabbit anti-MLL1 antibodies (A300-086A, A300-087A). Secondary: ReliaBLOT® reagents (WB120).MLL1 Antibody (A700-010) in WBDetection of human MLL1 by WB in 293T, HeLa, MCF1, HepG2, A459, and SW620 lysate. Antibody: Rabbit anti-MLL1 recombinant monoclonal [BL-175-7E8] (A700-010). Secondary: HRP-conjugated goat anti-rabbit IgG (A120-101P). |
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