Human TSG-6 ELISA Kit/人TSG-6 ELISA试剂盒
货号：EH472RB,EH472RBX5,EH472RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 0.2 ng/mL |
| 检测范围 | 0.2-50 ng/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | TNFAIP6 |
| Protein aliases | Hyaluronate-binding protein, TNF alpha-induced protein 6, TNF-stimulated gene 6 protein, TSG-6, Tumor necrosis factor alpha-induced protein 6, tumor necrosis factor alpha-inducible protein 6, tumor necrosis factor, alpha induced protein 6, alpha-induced protein 6, Tumor necrosis factor-inducible gene 6 protein, tumor necrosis factor-stimulated gene-6 protein |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | TNFAIP6, TSG-6, TSG6 |
| Gene ID | (Human) 7130 |
| Gene symbol | TNFAIP6 |
| UniProt ID | (Human) P98066 |
| Human TSG-6 quantitates human TSG-6 in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human TSG-6.人TSG-6定量检测血清，血浆，上清液中的人TSG-6。 该检测试剂盒将只识别天然和重组人TSG-6。Target information 靶标信息The TSG6 gene is transcribed in normal fibroblasts and activated by binding of the cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 sites in its promoter. TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein and the adhesion receptor CD44. TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain. TSG-6 is found in TNF-treated cells; its expression is rapidly activated by TNF alpha, IL-1 and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells and chondrocytes. The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis. TSG-6 forms a stable complex with components of the serine protease inhibitor, inter-alpha-inhibitor (I alpha I)). TSG-6 potentiates the inhibitory effect of l alpha l on the protease activity of plasmin. Through their cooperative inhibitory effect on plasmin, TSG-6 and l alpha l can modulate the protease network and thus inhibit inflammation.TSG6基因在正常的成纤维细胞中转录并通过其启动子中AP-1和NF-IL6位点的细胞因子TNFα和IL-1结合而被激活。 TSG-6是一种糖蛋白，是透明质酸结合蛋白家族的成员，该家族包括软骨连接蛋白，蛋白聚糖核心蛋白和粘附受体CD44。 TSG-6与CD44高度同源，尤其是在透明质酸结合域中。在TNF处理的细胞中发现了TSG-6；在正常的成纤维细胞，外周血单核细胞，滑膜细胞和软骨细胞中，其表达被TNFα，IL-1和脂多糖迅速激活。滑液中TSG-6的存在提示可能在类风湿关节炎中起作用。 TSG-6与丝氨酸蛋白酶抑制剂（α-间抑制剂（I alpha I））的组分形成稳定的复合物。 TSG-6增强了Iα1对纤溶酶的蛋白酶活性的抑制作用。通过它们对纤溶酶的协同抑制作用，TSG-6和Iα1可以调节蛋白酶网络，从而抑制炎症。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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