Human PILR-alpha ELISA Kit/人PILR-alpha ELISA试剂盒
货号：EH368RB,EH368RBX5,EH368RBX10
规格：96 tests,5X96 tests,10X96 tests
价格：6641,29884,57271
产品类型：Platinum ELISA
品牌：Thermo Fisher
物种：人
宿主：其它
抗体亚型：其它
荧光染料：其它
灵敏度 | 5.5 pg/mL |
| 检测范围 | 5.5-1,500pg/mL |
样本类型/体积 | 血清 50 μL 血浆 50 μL 上清液 50 μL |
操作时间 | 1 hr 20 min |
测试时间 | 4 hr 45 min |
Homogenous (no wash) | No |
| 批间变异系数（CV） | <12% |
| 批内变异系数（CV） | <10% |
仪器设备 | Colorimetric Microplate Reader 酶标仪 |
规格 | 5 x 96 Tests |
组份 | - 预包被96孔板 - 标准品 - 测定稀释浓缩液 - 生物素化检测抗体 - SAV-HRP - 洗涤液 - 显色剂 - 终止液 - 胶板盖 |
储存温度 | 2-8℃ |
| Protein name | PILRA |
| Protein aliases | Cell surface receptor FDF03, Inhibitory receptor PILR-alpha, paired immunoglobin-like type 2 receptor alpha, Paired immunoglobulin-like type 2 receptor alpha |
物种（Tested） | 人 |
试剂盒类型 | Sandwich ELISA Kit |
标记（染料） | HRP |
| 检测抗体偶联物 | Biotin |
| Gene aliases | FDF03, PILRA |
| Gene ID | (Human) 29992 |
| Gene symbol | PILRA |
| UniProt ID | (Human) Q9UKJ1 |
| Human PILR-alpha quantitates human PILR-alpha in serum, plasma, supernatant. The assay will exclusively recognize both natural and recombinant human PILR-alpha.人PILR-alpha定量检测血清，血浆，上清液中的人PILR-alpha。该检测试剂盒将专门识别天然和重组人PILR-α。Target information 靶标信息SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILR beta-mediated activation. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILR alpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role.SHP-1介导的蛋白质酪氨酸残基的去磷酸化是调节几种细胞信号通路的关键。两种类型的抑制受体超家族成员是基于免疫受体酪氨酸的抑制性基序（ITIM）受体和它们的非ITIM活化受体。人们认为通过SHP-1控制细胞信号传导是通过PILRalpha介导的抑制作用与PILR beta介导的激活之间的平衡来实现的。该特定基因编码受体对中带有ITIM的成员，该成员具有抑制作用。细胞信号传导途径依赖于激活和抑制过程之间的动态相互作用。 SHP-1介导的蛋白质酪氨酸残基的去磷酸化是调节几种细胞信号通路的关键。两种类型的抑制受体超家族成员是基于免疫受体酪氨酸的抑制性基序（ITIM）受体和它们的非ITIM活化受体。人们认为通过SHP-1控制细胞信号传导是通过PILRα介导的抑制与PILRbeta介导的激活之间的平衡来实现的。这些成对的免疫球蛋白样受体基因在染色体7上头尾相接。该特定基因编码受体对中带有ITIM的成员，该成员具有抑制作用。For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.仅供研究使用。 不用于诊断过程。 未经明确授权不得转售。 |
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